In the wake of the US Supreme Court’s 2022 Dobbs v Jackson Women’s Health Organization decision, which overturned federal protections on abortion, obstetrician-gynecologists (OB-GYNs) face policy-related threats to their personal and professional wellbeing. The Study of OB-GYNs in Post-Roe America (SOPRA) investigates the relationships between state abortion policy environments, OB-GYNs’ work experiences and stressors, and their health and wellbeing. It also identifies organizational-level policies and practices that may buffer negative effects of policy-related stressors on OB-GYNs. By generating rigorous scientific evidence and actionable recommendations to help healthcare organizations support OB-GYNs, SOPRA aims to protect and promote the health and wellbeing of this essential workforce.